Author

F. Mikaeloff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 6 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:metabolomics· 2

Frequent Co-Authors

U. Neogi· 7 shared A. Vegvari· 5 shared E. Saccon· 4 shared S. Gupta· 4 shared A. Mirazimi· 3 shared A. Sonnerborg· 3 shared J. E. Rodriguez· 3 shared M. Sperk· 3 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersMicrobiology

U. Neogi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Excessive inflammatory and metabolic responses to acute SARS-CoV-2 infection are associated with a distinct gut microbiota composition

W. C. Albrich, T. S. Ghosh, S. Ahearn-Ford, F. Mikaeloff, N. Lunjani, B. Forde, N. Suh, G.-R. Kleger, U. Pietsch, M. Frischknecht, C. Garzoni, R. Forlenza, M. Horgan, C. Sadlier, T. R. Negro, , L. O'Mahony

This study identifies distinct gut microbiota compositions and metabolic/cytokine profiles associated with severe outcomes in SARS-CoV-2 infection.

bioRxiv · Oct 26, 2021 · PreprintImmunology

Implications of central carbon metabolism in SARS-CoV-2 replication and disease severity

S. Krishnan, H. Nordqvist, A. T. Ambikan, S. Gupta, M. Sperk, S. Svensson-Akusjarvi, F. Mikaeloff, R. Benfeitas, E. Saccon, S. M. Ponnan, J. E. Rodriguez, N. Nikouyan, A. Odeh, G. Ahlen, M. Asghar, , U. Neogi

This study investigates how SARS-CoV-2 affects central carbon metabolism in host cells and links metabolic changes to disease severity.

bioRxiv · Feb 24, 2021Microbiology

Cytotoxic lymphocytes target HIV-1 Gag through granzyme M-mediated cleavage

E. Saccon, F. Mikaeloff, P. Figueras Ivern, A. Vegvari, A. Sonnerborg, U. Neogi, R. van Domselaar

This study shows that granzyme M from cytotoxic lymphocytes cleaves HIV-1 Gag, potentially controlling infection without killing infected cells.

bioRxiv · Feb 24, 2021Immunology

Type-I interferon signatures in SARS-CoV-2 infected Huh7 cells

X. Chen, E. Saccon, K. S. Appelberg, F. Mikaeloff, J. E. Rodriguez, B. S. Vinhas, T. Frisan, A. Vegvari, A. Mirazimi, U. Neogi, S. Gupta

This study identifies delayed and dysregulated type-I interferon signaling in SARS-CoV-2 infected Huh7 cells and shows that IFN-I pretreatment reduces susceptibility.

bioRxiv · Feb 4, 2021Microbiology

Tropism of SARS-CoV-2 in commonly used laboratory cell lines and their proteomic landscape during infection

E. Saccon, X. Chen, F. Mikaeloff, J. E. Rodriguez, L. Szekely, B. S. Vinhas, S. Krishnan, S. Byrareddy, T. Frisan, A. Vegvari, A. Mirazimi, U. Neogi, S. Gupta

This study assesses SARS-CoV-2 tropism and proteomic changes in human cell lines, finding cell-type-specific susceptibility and interferon signaling dysregulation.

bioRxiv · Aug 28, 2020Microbiology

Distinct lipid profile, low-level inflammation and increased antioxidant defense as a signature in HIV-1 elite control status

M. Sperk, F. Mikaeloff, S. Svensson Akusjarvi, S. M. Ponnan, P. Nowak, A. Sonnerborg, U. Neogi

This study identifies a distinct lipid profile, reduced inflammation, and increased antioxidant defense in HIV-1 elite controllers compared to viremic progressors and healthy controls.

bioRxiv · Jul 2, 2020Microbiology

Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

S. Appelberg, S. Gupta, A. T. Ambikan, F. Mikaeloff, A. Vegvari, S. Svensson Akusjarvi, R. Benfeitas, M. Sperk, M. Stahlberg, S. Krishnan, K. Singh, J. M. Penninger, A. Mirazimi, U. Neogi

The paper identifies dysregulation in mTOR/HIF-1 signaling in SARS-CoV-2 infected cells through proteo-transcriptomics analysis.

bioRxiv · Apr 30, 2020Microbiology