Cancer BiologybioRxiv
Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
A. Garcia-Gomez, T. Li, J. Rodriguez-Ubreva…·E. Ballestar
This study identifies aberrant DNA methylation in mesenchymal stromal cells from myeloma patients and shows that targeting DNMTs and G9a with CM-272 reverses bone loss and reduces tumor burden.
DOI 10.1038/s41467-020-20715-x