F. Catala-Moll

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.

Gut Microbiome Signatures Linked to HIV-1 Reservoir Size and Viremia Control

The paper identifies gut microbiome signatures, specifically the Bacteroidales/Clostridiales ratio, associated with HIV-1 reservoir size and viremia control in a clinical trial.

The JAK2-STAT pathway epigenetically regulates tolerized genes during the first encounter with bacterial antigens

The paper identifies JAK2-STAT pathway involvement in epigenetic regulation of tolerized genes during first bacterial antigen exposure, showing its role in modulating inflammatory responses.

Vitamin D receptor and STAT3 cooperate to establish TET2-mediated tolerogenesis

This study shows that VDR and STAT3 cooperate with TET2 to induce DNA demethylation and tolerogenesis in dendritic cells through vitamin D signaling.

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

This study identifies aberrant DNA methylation in mesenchymal stromal cells from myeloma patients and shows that targeting DNMTs and G9a with CM-272 reverses bone loss and reduces tumor burden.

Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction

This study investigates AID's role in DNA methylation defects in HIGM2 B cells, finding that AID is not directly involved in active demethylation but TET enzymes are, and that methylation defects are linked to premature BCR activation.