L. Ciudad

Purinergic Preconditioning Induces Epigenomic and Transcriptomic Changes Resembling Epilepsy-associated Microglial States

This study shows ATP-mediated preconditioning induces epigenomic and transcriptomic changes in microglia-like cells that resemble epilepsy-associated microglial states.

Vitamin C triggers NF-κB-driven epigenetic reprogramming and enhanced immunogenic responses in dendritic cells

This study shows vitamin C induces epigenetic changes and enhances immunogenic responses in dendritic cells through NF-κB and TET2 interactions.

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.

MAFB surrogates the glucocorticoid receptor ability to induce tolerogenesis in dendritic cells

This study identifies MAFB as a key mediator of GC-induced tolerogenesis in dendritic cells, showing its role in epigenomic and transcriptomic remodeling.

The JAK2-STAT pathway epigenetically regulates tolerized genes during the first encounter with bacterial antigens

The paper identifies JAK2-STAT pathway involvement in epigenetic regulation of tolerized genes during first bacterial antigen exposure, showing its role in modulating inflammatory responses.

Vitamin D receptor and STAT3 cooperate to establish TET2-mediated tolerogenesis

This study shows that VDR and STAT3 cooperate with TET2 to induce DNA demethylation and tolerogenesis in dendritic cells through vitamin D signaling.

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

This study identifies aberrant DNA methylation in mesenchymal stromal cells from myeloma patients and shows that targeting DNMTs and G9a with CM-272 reverses bone loss and reduces tumor burden.