J. Rodriguez-Ubreva

Divergent Epigenetic and Transcriptomic Reprogramming of Monocyte Subpopulations in Systemic Lupus Erythematosus

This study identifies epigenetic and transcriptomic changes in SLE monocyte subsets, linking them to disease activity and function.

Single-Cell Atlas of Common Variable Immunodeficiency reveals germinal center-associated epigenetic dysregulation in B cell responses

The paper creates a single-cell atlas of CVID, identifying epigenetic and transcriptional defects in memory B cells and linking them to impaired cell communication.

Vitamin D receptor and STAT3 cooperate to establish TET2-mediated tolerogenesis

This study shows that VDR and STAT3 cooperate with TET2 to induce DNA demethylation and tolerogenesis in dendritic cells through vitamin D signaling.

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

This study identifies aberrant DNA methylation in mesenchymal stromal cells from myeloma patients and shows that targeting DNMTs and G9a with CM-272 reverses bone loss and reduces tumor burden.

Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction

This study investigates AID's role in DNA methylation defects in HIGM2 B cells, finding that AID is not directly involved in active demethylation but TET enzymes are, and that methylation defects are linked to premature BCR activation.