AADAT-Driven Metabolic Control of Malate and CoQ10 Shapes Immune Evasion in Triple-Negative Breast Cancer
Megha Chatterjee, Franklin Gu, Susmita Samanta, Uttam Rasaily, Sai Manohar Thota, Dana Varghese, YUNPING QIU, Lynette Ewura Esi Fordwuo, Hugo J. Villanueva, Mary Kathryn McKenna, Jun Hyoung Park, Weijie Zhang, Lin Hai Tian, Liqun Yu, Badrajee Piyarathna, , Arun Sreekumar
This paper identifies AADAT as a metabolic immune checkpoint in TNBC that promotes immune evasion by regulating malate and CoQ10, and shows that malate supplementation can reverse immunotherapy resistance.
bioRxiv · Jan 30, 2026 · PreprintCancer Biology