L. Harris

Spatial Transcriptomic Sequencing of a DIPG-infiltrated Brainstem reveals Key Invasion Markers and Novel Ligand-Receptor Pairs contributing to Tumour to TME Crosstalk

This study uses spatial transcriptomics to analyze a DIPG-infiltrated brainstem, identifying invasion markers and ligand-receptor pairs involved in tumour-TME crosstalk.

Intracellular pH differentially regulates transcription of metabolic and signaling pathways in normal epithelial cells

The paper shows that intracellular pH changes regulate transcription of signaling and metabolic pathways in normal epithelial cells, with high pH increasing Notch1 and glycolytic gene expression.

Gene Expression Meta-Analysis Reveals Interferon-induced Genes

This paper uses gene set enrichment analysis to identify interferon-induced genes associated with SARS-CoV infections across human and mouse models.

IGF targeting perturbs global replication through ribonucleotide reductase dysfunction

This study shows that IGF-1R inhibition causes replication stress by reducing RNR subunit RRM2, leading to DNA damage and synthetic lethality with ATM loss in cancer cells.

Among-individual diet variation within a lake trout ecotype: lack of stability of niche use.

The paper examines diet variation among lake trout within an ecotype, finding that individual trophic specialization occurs despite lack of genetic or morphological differentiation.

Lagging strand encoding promotes adaptive evolution

The paper investigates whether lagging strand genes evolve faster due to replication-transcription conflicts and finds convergent mutations are enriched in these genes, suggesting adaptive evolution.

Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing

This study uses longitudinal single-cell RNA sequencing to reveal therapy-induced adaptations in lung cancer, identifying cell state transitions and pathways associated with treatment response and resistance.