Disrupting the Transmembrane Domain Oligomerization of Protein Tyrosine Phosphatase Receptor J Promotes its Activity in Cancer Cells
E. Bloch, E. Sikorski, D. Pontoriero, B. W. Berger, M. J. Lazzara, D. Thevenin
This study shows that disrupting the transmembrane domain oligomerization of PTPRJ enhances its activity, reduces EGFR phosphorylation, and promotes substrate access in cancer cells.
bioRxiv · Oct 7, 2019Biochemistry