A. Sabnis

IS1-related large-scale deletion of chromosomal regions harbouring oxygen-insensitive nitroreductase gene nfsB causes nitrofurantoin heteroresistance in Escherichia coli

The paper identifies IS1-mediated chromosomal deletions in nfsB as a novel mechanism of nitrofurantoin heteroresistance in E. coli.

Synergistic Activity of Repurposed Peptide Drug Glatiramer Acetate with Tobramycin Against Cystic Fibrosis Pseudomonas aeruginosa

This study shows that glatiramer acetate enhances tobramycin's effectiveness against Pseudomonas aeruginosa in cystic fibrosis patients by reducing MICs and disrupting bacterial membranes.

Colistin resistance in Escherichia coli confers protection of the cytoplasmic but not outer membrane from the polymyxin antibiotic

This study shows that colistin resistance in E. coli protects the cytoplasmic but not outer membrane from colistin, regardless of resistance mechanism.

Colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane

This study reveals that colistin kills bacteria by targeting lipopolysaccharide in the cytoplasmic membrane, not the outer membrane, and shows that murepavadin can enhance its efficacy.

Effect of host-mimicking medium and biofilm growth on the ability of colistin to kill Pseudomonas aeruginosa.

This study shows that Pseudomonas aeruginosa in CF-mimicking media and ex vivo models exhibits higher colistin tolerance due to poor antibiotic penetration, highlighting the need for better biofilm penetration assays.