Pharmacology & ToxicologybioRxiv
Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Z. Vuckovic, J. Wang, V. Pham…·D. M. Thal
The paper presents cryo-EM structures of the M4 mAChR with ligands and modulators, revealing structural and dynamic insights into allosteric modulation and receptor activation mechanisms.