Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides
J. Guan, C. Spry, E. Tjhin, P. Yang, T. Kittikool, V. Howieson, H. Ling, L. Starrs, G. Burgio, K. J. Saliba, K. Auclair
This study replaces the amide group in pantothenamides with heteroaromatic rings to improve antiplasmodial activity against Plasmodium species.
bioRxiv · Oct 2, 2020Pharmacology & Toxicology