Author

K. J. Saliba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 5 Organism:plant (other)· 4 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

C. Spry· 4 shared A. G. Maier· 2 shared E. T. Tjhin· 2 shared G. G. van Dooren· 2 shared K. Auclair· 2 shared V. M. Howieson· 2 shared A. E. Sexton· 1 shared A. Hemasa· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersPharmacology & Toxicology

C. Spry

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Author profile →

6 papers

Recent·Most cited

Roseoflavin, a natural riboflavin analogue, possesses in vitro and in vivo antiplasmodial activity

A. Hemasa, M. Mack, K. J. Saliba

This study identifies roseoflavin as an antimalarial compound that inhibits Plasmodium parasite growth by targeting riboflavin metabolism and cofactor utilization, showing in vitro and in vivo efficacy.

bioRxiv · Apr 14, 2022Pharmacology & Toxicology

A screen of drug-like molecules identifies chemically diverse electron transport chain inhibitors in apicomplexan parasites

J. A. Hayward, F. V. Makota, D. Cihalova, E. Rajendran, S. M. Zwahlen, L. Shuttleworth, U. Wiedemann, C. Spry, K. J. Saliba, A. G. Maier, G. G. van Dooren

The paper screens drug-like molecules to identify new electron transport chain inhibitors in apicomplexan parasites, finding chemically diverse compounds effective against resistant strains.

bioRxiv · Feb 13, 2022Microbiology

Purification of functional Plasmodium falciparum tubulin allows for the identification of parasite-specific microtubule inhibitors

W. G. Hirst, D. Fachet, B. Kuropka, C. Weise, K. J. Saliba, S. Reber

This study purifies functional Plasmodium falciparum tubulin and identifies parasite-specific microtubule inhibitors that selectively disrupt protozoan microtubule growth.

bioRxiv · May 25, 2021Biochemistry

A novel heteromeric pantothenate kinase complex in apicomplexan parasites

E. T. Tjhin, V. M. Howieson, C. Spry, G. G. van Dooren, K. J. Saliba

The paper identifies heteromeric pantothenate kinase complexes in Plasmodium falciparum and Toxoplasma gondii, showing that PanK1 and PanK2 form functional complexes with Pf14-3-3I and are essential for parasite proliferation.

bioRxiv · Mar 16, 2021Biochemistry

Exploring heteroaromatic rings as a replacement for the labile amide of antiplasmodial pantothenamides

J. Guan, C. Spry, E. Tjhin, P. Yang, T. Kittikool, V. Howieson, H. Ling, L. Starrs, G. Burgio, K. J. Saliba, K. Auclair

This study replaces the amide group in pantothenamides with heteroaromatic rings to improve antiplasmodial activity against Plasmodium species.

bioRxiv · Oct 2, 2020Pharmacology & Toxicology

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

E. T. Tjhin, C. Spry, A. L. Sewell, A. Hoegl, L. Barnard, A. E. Sexton, V. M. Howieson, A. G. Maier, D. J. Creek, E. Strauss, R. Marquez, K. Auclair, K. J. Saliba

The paper identifies mutations in Plasmodium falciparum pantothenate kinase genes that confer resistance to pantothenate analogues and reveal different mechanisms of action for these compounds.

bioRxiv · Jul 24, 2017Pharmacology & Toxicology