Hedgehog pathway inhibitors significantly reduce the formation of heterotopic ossification in a direct trauma/burn mouse model
A. Chakraborty, J. Gvozdenovic-Jeremic, F. Wang, S. W. Hoag, E. Vert-Wong, R. M. Pearson
This study shows that Hedgehog pathway inhibitors reduce heterotopic ossification in a trauma/burn mouse model by inhibiting osteoblast differentiation and systemic inflammation.
bioRxiv · Jan 31, 2021 · PreprintPharmacology & Toxicology