EGFR transactivates RON to drive oncogenic crosstalk
C. Franco Nitta, E. W. Green, E. D. Jhamba, J. M. Keth, I. Ortiz-Caraveo, R. M. Grattan, D. J. Schodt, A. C. Gibson, A. Rajput, K. A. Lidke, M. P. Steinkamp, B. S. Wilson, D. S. Lidke
This study identifies EGFR-dependent phosphorylation of RON and shows direct EGFR-RON interactions drive oncogenic crosstalk, contributing to therapeutic resistance.
bioRxiv · Aug 11, 2020 · PreprintCancer Biology