Author

R. M. Grattan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Research Focus:imputation· 2 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

D. S. Lidke· 4 shared K. A. Lidke· 3 shared B. S. Wilson· 2 shared D. J. Schodt· 2 shared A. Auer· 1 shared A. C. Gibson· 1 shared A. K. N. Shotorban· 1 shared A. Rajput· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiophysics

D. S. Lidke

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Author profile →

4 papers

Recent·Most cited

Axial de-scanning using remote focusing in the detection arm of light-sheet microscopy

H. Dibaji, A. K. N. Shotorban, R. M. Grattan, S. Lucero, D. J. Schodt, K. A. Lidke, J. Petruccelli, D. S. Lidke, S. Liu, T. Chakraborty

This paper introduces a novel optical design for axial de-scanning in light-sheet microscopy's detection arm, enabling aberration-free, multi-color volumetric imaging without sample translation.

bioRxiv · Sep 7, 2023Biophysics

Antigen properties shape organization of FcεRI aggregates to tune mast cell signaling

D. A. Rinaldi, W. K. Kanagy, R. M. Grattan, J. C. David, H. C. Kaye, E. A. Burns, S. R. Lucero, M. P. Perez, M. J. Wester, L. Tapia, B. Jacobson, K. A. Lidke, B. S. Wilson, D. S. Lidke

This study shows that antigen properties like valency and epitope spacing shape FcεRI aggregate structure, influencing mast cell signaling outcomes.

bioRxiv · Aug 4, 2023 · PreprintBiophysics

Simultaneous multicolor fluorescence imaging using duplication-based PSF splitting

R. Van den Eynde, F. Hertel, S. Abakumov, B. Krajnik, S. Hugelier, A. Auer, J. Hellmeier, T. Schlichthaerle, R. M. Grattan, D. S. Lidke, R. Jungmann, M. Leutenegger, W. Vandenberg, P. Dedecker

The paper introduces a method to enhance fluorescence imaging by splitting the PSF into multiple copies, enabling simultaneous multicolor imaging with super-resolution and single-molecule capabilities.

bioRxiv · Oct 4, 2022 · PreprintBiophysics

EGFR transactivates RON to drive oncogenic crosstalk

C. Franco Nitta, E. W. Green, E. D. Jhamba, J. M. Keth, I. Ortiz-Caraveo, R. M. Grattan, D. J. Schodt, A. C. Gibson, A. Rajput, K. A. Lidke, M. P. Steinkamp, B. S. Wilson, D. S. Lidke

This study identifies EGFR-dependent phosphorylation of RON and shows direct EGFR-RON interactions drive oncogenic crosstalk, contributing to therapeutic resistance.

bioRxiv · Aug 11, 2020 · PreprintCancer Biology