Author

K. Calkins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Animal Behavior & Cognition· 1 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. chakhoyan· 1 shared A. Chu· 1 shared A. Hofmann· 1 shared A. Vulpetti· 1 shared B. Bauer-Probst· 1 shared B. Chung· 1 shared B. Pinch· 1 shared C. R. Thoma· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperAnimal Behavior & Cognition

A. chakhoyan

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2 papers

Recent·Most cited

The maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehavioral impairment in mice

E. Coley, G. Lum, G. Pronovost, E. Ozcan, K. Yu, J. Mcdermott, A. chakhoyan, E. Goldman, H. Vuong, J. Paramo, A. Chu, K. Calkins, E. Y. Hsiao

This study shows that maternal microbiome alterations during protein undernutrition in mice modify offspring neurobehavioral impairments, with microbiome-targeted interventions offering potential mitigation.

bioRxiv · Feb 22, 2024 · PreprintAnimal Behavior & Cognition

Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings

M. Schroeder, M. Renatus, X. Liang, F. Meili, S. Ferrand, F. Gauter, X. Li, F. Sigoillot, S. Gleim, M.-T. Stachyra, J. Thomas, M. Schirle, T. Zoller, D. Begue, P. Lefeuvre, , C. R. Thoma

This study develops DCAF1-based PROTACs to overcome CRBN resistance in targeted protein degradation, demonstrating effective degradation of BTK in CRBN-resistant cells.

bioRxiv · Apr 9, 2023 · PreprintBiochemistry