J. McDermott

The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions

This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.

The maternal microbiome modifies adverse effects of protein undernutrition on offspring neurobehavioral impairment in mice

This study shows that maternal microbiome alterations during protein undernutrition in mice modify offspring neurobehavioral impairments, with microbiome-targeted interventions offering potential mitigation.

The genomic landscape of early stage ovarian high grade serous carcinoma

This study compares genomic features of early and late stage high grade serous ovarian carcinoma, finding no unique mutations or focal copy number alterations but noting differences in ploidy and copy number signatures.

Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance.

The paper identifies two prognostic cervical squamous cell carcinoma subtypes across three continents, revealing conserved molecular and immune features.

Novel syngeneic animal model of tobacco-associated oral cancer reveals the activity of in situ anti-CTLA-4

This paper develops a syngeneic mouse model of tobacco-associated HNSCC that shows high response rates to anti-CTLA-4 therapy.

TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating SMAD2/3 transcription factors

This paper demonstrates that TNAP negatively regulates TGF-β signaling by dephosphorylating SMAD2/3, thereby limiting cardiac and skeletal muscle fibrosis.