Blood flow-induced Notch activation and endothelial migration enable embryonic vascular remodeling.
Bart G. M. W. Weijts, Edgar Gutierrez, Semion K. Saikin, Ararat J. Ablooglu, David J. Traver, Alex Groisman, Eugene Tkachenko
The paper shows that blood flow direction determines endothelial cell fate during vascular remodeling, with venous flow promoting vein formation and arterial flow preventing it.
bioRxiv · Jul 9, 2018 · PreprintDevelopmental Biology