David J. Traver

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

The paper shows that endothelial cells from the dermomyotome contribute to the dorsal aorta and support hematopoietic stem cell emergence in zebrafish.

Endothelial struts, a mechanism to generate large lumenized blood vessels de novo

This paper describes a new mechanism for forming large diameter blood vessels through endothelial struts that act as scaffolds during vasculogenesis.

Zebrafish Kit ligands cooperate with erythropoietin to promote erythroid cell expansion

The paper shows that Kit ligands cooperate with erythropoietin to promote erythroid cell expansion in zebrafish and reports ex vivo suspension cultures of zebrafish hematopoietic progenitor cells.

In vivo lineage conversion of vertebrate muscle into early endoderm-like cells

This study shows that differentiated zebrafish muscle cells can be reprogrammed into endoderm-like cells in vivo through Sox32 and Oct4 co-expression, challenging previous assumptions about lineage restriction.

EGFR confers exquisite specificity of Wnt9a-Fzd9b signaling in hematopoietic stem cell development

The paper shows EGFR is required for Wnt9a-Fzd9b signaling specificity in HSPC development, identifying key domains and phosphorylation events.

Blood flow-induced Notch activation and endothelial migration enable embryonic vascular remodeling.

The paper shows that blood flow direction determines endothelial cell fate during vascular remodeling, with venous flow promoting vein formation and arterial flow preventing it.