Alex Groisman

Neural pathways linking hypoxia with pectoral fin movements in Danio rerio

The paper identifies neural pathways in zebrafish larvae that link hypoxia detection by skin-resident neuroendocrine cells to increased pectoral fin movements and heart activity.

Environmental sensing in dynamic quorum responses

The paper shows quorum sensing in bacteria can detect environmental changes and uses a new signaling mechanism involving protein synthesis and dilution rates to process dynamic inputs.

Blood flow-induced Notch activation and endothelial migration enable embryonic vascular remodeling.

The paper shows that blood flow direction determines endothelial cell fate during vascular remodeling, with venous flow promoting vein formation and arterial flow preventing it.

Hyperactive Rac1 drives MAPK-independent proliferation in melanoma by assembly of a mechanosensitive dendritic actin network

This paper shows that a Rac1 mutation drives melanoma proliferation independently of MAPK signaling by forming a mechanosensitive actin network that inactivates the tumor suppressor NF2/Merlin.

Organized spatial patterns of activated β2 integrins in arresting neutrophils

The paper uses superresolution microscopy and molecular modeling to identify spatial patterns of activated β2 integrins on neutrophils during arrest.

Rigidity of silicone substrates controls cell spreading and stem cell differentiation

This study investigates how the rigidity of silicone substrates affects cell spreading and stem cell differentiation, resolving conflicting findings about the role of substrate elasticity versus porosity.