PRMT1 arginine methylation of MCM4 restricts ssDNA gap formation during DNA replication
Michael W. Ferguson, Cassandra J. Wong, Xiaohan Yang, Edith Cheng, Antonio Mollica, Shahir M. Morcos, Wade H. Dunham, Zhen-Yuan Lin, Eric I. Campos, Anne‐Claude Gingras, Grant W. Brown
This study identifies PRMT1 as a replisome-associated methyltransferase that suppresses ssDNA gap formation by methylating MCM4, thereby maintaining fork integrity during DNA replication.
bioRxiv · Jun 4, 2026 · PreprintMolecular Biology