Author

Shahir M. Morcos

University of TorontoORCID 0000-0002-5592-3086Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Assay:metagenomics· 1 Assay:multiome· 1 Assay:proteomics· 1

Frequent Co-Authors

Eric I. CamposiD· 3 shared Anne‐Claude GingrasiD· 2 shared Cassandra J. WongiD· 2 shared Giovanni L. BurkeiD· 2 shared Ahmed Abosen· 1 shared Alejandro Saettone· 1 shared Antonio MollicaiD· 1 shared Ayala Milo· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMolecular Biology

Eric I. CamposORCID

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Author profile →

3 papers

Recent·Most cited

ZNF121 recruits YTHDF2 to modulate mRNA stability

Giovanni L. Burke, Syed Nabeel‐Shah, Shuye Pu, Nujhat Ahmed, Shahir M. Morcos, James D. Burns, Ahmed Abosen, Guoqing Zhong, Eric I. Campos, Jack F. Greenblatt

The paper identifies ZNF121 as a cofactor that enhances YTHDF2-mediated mRNA decay by facilitating its binding to target transcripts, thereby modulating mRNA stability and cell-cycle regulation.

Cell Reports · Sep 22, 2026Peer-reviewedMolecular Biology

PRMT1 arginine methylation of MCM4 restricts ssDNA gap formation during DNA replication

Michael W. Ferguson, Cassandra J. Wong, Xiaohan Yang, Edith Cheng, Antonio Mollica, Shahir M. Morcos, Wade H. Dunham, Zhen-Yuan Lin, Eric I. Campos, Anne‐Claude Gingras, Grant W. Brown

This study identifies PRMT1 as a replisome-associated methyltransferase that suppresses ssDNA gap formation by methylating MCM4, thereby maintaining fork integrity during DNA replication.

bioRxiv · Jun 4, 2026 · PreprintMolecular Biology

H3.3 De Novo Mutations Alter Lysine 36 Methylation via Distinct Mechanisms

Shahir M. Morcos, Sabina Sarvan, Alejandro Saettone, Cassandra J. Wong, Scott Vo, Ayala Milo, Omar H. Bayoumy, Rajesh Angireddy, Giovanni L. Burke, Jack Greenblatt, Nada Jabado, Carol Chen, Elizabeth J. K. Bhoj, Anne‐Claude Gingras, Jean‐François Couture, Eric I. Campos

This study investigates how BLBS-causing H3.3 mutations affect H3K36 methylation and effector protein binding, revealing molecular similarities across mutations.

bioRxiv · Sep 9, 2025 · PreprintMolecular Biology