Microbiota-derived short chain fatty acids promote Aβ plaque deposition
Alessio Vittorio Colombo, Rebecca Sadler, Gemma Llovera, Vikramjeet Singh, Stefan Roth, Steffanie Heindl, Laura Sebastián Monasor, Aswin Verhoeven, Finn Peters, Samira Parhizkar, Frits Kamp, Mercedes Gomez de Agüero, Andrew James Macpherson, Edith Winkler, Jochen Wolfgang Herms, , Arthur Liesz
This study shows that microbiota-derived short chain fatty acids (SCFA) increase Aβ plaque deposition in Alzheimer's disease by promoting microglial activation and ApoE upregulation.
eLife · Apr 12, 2021Peer-reviewedNeuroscience