PRDM16 controls smooth muscle cell fate in atherosclerosis
Josephine M. E. Tan, Lan Cheng, Ryan P. Calhoun, Angela H. Weller, Karima Drareni, Skylar Fong, Eirlys Barbara, Hee‐Woong Lim, Chenyi Xue, Hanna Winter, Gaelle E Auguste, Clint L. Miller, Muredach P. Reilly, Lars Mäegdefessel, Esther Lutgens, Patrick Seale
This study shows PRDM16 maintains SMC identity and regulates atherosclerotic plaque composition by inhibiting synthetic gene programs during SMC fate switching.
Nature Cardiovascular Research · Oct 17, 2025Peer-reviewedMolecular Biology