SOX4 Reprograms Adipose Stromal Cells into a Cancer-Associated Fibroblast-like State to Drive Metabolic Disease
Karima Drareni, Ryan P. Calhoun, Lan Cheng, Camille E. M Piquet, Lin Liu, Sarah Traynor, Josephine M. E. Tan, Marco Angelozzi, David Merrick, Véronique Lefèbvre, Patrick Seale
This study shows that SOX4 reprograms adipose stromal cells into CAF-like cells in obesity, promoting metabolic disease through TGFβ and MDK signaling.
bioRxiv · Sep 28, 2026 · PreprintCell Biology