Patrick Seale

This study shows that SOX4 reprograms adipose stromal cells into CAF-like cells in obesity, promoting metabolic disease through TGFβ and MDK signaling.

This study investigates how the GKRP P446L variant affects hepatic lipid and cholesterol metabolism by reducing GCK activity and increasing cholesterol synthesis.

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

This study shows PRDM16 maintains SMC identity and regulates atherosclerotic plaque composition by inhibiting synthetic gene programs during SMC fate switching.

This study identifies IRF2BP2 as a repressor of adipocyte lipolysis, showing its role in regulating lipolysis-related genes and metabolic homeostasis.

This paper identifies shared and unique chromatin accessibility and 3D interactions of SUD loci, implicating non-neural cell types like pancreatic β-cells and showing a causal link between T2D and AUD.

This study shows aging impairs beige adipogenesis and adipocyte metabolic responses to cold, identifies Npr3 as a marker gene, and provides insights into age-related adipose tissue dysfunction.

This study identifies the cellular origins of perivascular adipose tissue using single-cell transcriptomics, fate mapping, and adipogenesis assays, revealing fibroblastic and smooth muscle progenitors.