Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of ER+ breast cancer brain metastases in young and aged hosts
Morgan S. Fox, Jenny A. Jaramillo-Gómez, Ricaurte Alejandro Marquez-Ortíz, Karen L.F. Alvarez-Eraso, Maria Jose Contreras-Zarate, Trinh C. Pham, Elaina N. Barela, Stella N. Koliavas, Peter Kabos, Natalie J. Serkova, Carol A. Sartorius, Elizabeth A. Wellberg, Diana M. Cittelly
This study shows FGFR1 amplification drives ER+ breast cancer brain metastasis in young and aged mice via FGF2 and NCAM1 interactions, with FGFR inhibitors effective in early stages.
Nature Communications · May 28, 2026Peer-reviewedCancer Biology