Diana M. Cittelly

This study shows estradiol suppresses microglial immunity and promotes breast cancer brain metastasis, with E2 suppression enhancing anti-tumor responses and synergizing with radiotherapy.

This study shows that NTRK inhibitors can reduce brain metastases in lung cancers with wild-type NTRK, even without NTRK fusions.

This study shows FGFR1 amplification drives ER+ breast cancer brain metastasis in young and aged mice via FGF2 and NCAM1 interactions, with FGFR inhibitors effective in early stages.

This study develops a metastatic ILC mouse model to study organ tropism, endocrine response, and bone remodeling in mILC.

This study identifies Wnt signaling activation as a mechanism of PARP inhibitor resistance in HGSOC and shows that combining PARPi with Wnt inhibitors reduces tumor burden.