Carol A. Sartorius

Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of ER+ breast cancer brain metastases in young and aged hosts

This study shows FGFR1 amplification drives ER+ breast cancer brain metastasis in young and aged mice via FGF2 and NCAM1 interactions, with FGFR inhibitors effective in early stages.

Maf1 Cooperates with Progesterone Receptor to Repress RNA Polymerase III Transcription of Select tRNAs

The paper shows that Maf1 and PR work together to reduce tRNA transcription in breast cancer cells under progestin treatment.

Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cells

This study identifies lipid metabolic reprogramming in endocrine-resistant breast cancer cells, showing TVB-2640 reduces lipid storage but not cell growth.

Metabolic Switch in Endocrine Resistant Estrogen Receptor Positive Breast Cancer

This study investigates how metabolic changes in endocrine-resistant ER+ breast cancer cells affect ER DNA-binding patterns and shows that DMF can restore sensitivity to endocrine therapies by targeting metabolic vulnerabilities.

Estradiol (E2) concentration shapes the chromatin binding landscape of the estrogen receptor

The paper shows that estradiol concentration changes the chromatin binding sites of the estrogen receptor, affecting its localization and interaction with DNA motifs.

Mapping Transcription Factor-Nucleosome Dynamics from Plasma cfDNA

This paper maps transcription factor-nucleosome dynamics from plasma cfDNA to identify cancer states and tissue-of-origin.

Recovery and analysis of transcriptome subsets from pooled single-cell RNA-seq libraries

The paper develops a method to recover and analyze targeted transcriptome subsets from scRNA-seq libraries, improving sequencing depth and gene detection.