Cancer BiologyNeuro-OncologyPeer-reviewed
Estradiol Reprograms Microglia to Create an Immune-Suppressed Niche Permissive to Breast Cancer Brain Metastasis
Karen L.F. Alvarez-Eraso, Maria Jose Contreras-Zarate, Andrew E. Goodspeed…·Diana M. Cittelly
This study shows estradiol suppresses microglial immunity and promotes breast cancer brain metastasis, with E2 suppression enhancing anti-tumor responses and synergizing with radiotherapy.