G-quadruplexes represent promising new targets to overcome multidrug-resistant fungal infections
Georgie Middleton, Fuad O Mahamud, Isabelle S. R. Storer, Abigail Williams-Gunn, Finn Wostear, Alireza Abdolrasouli, Elaine Barclay, Alice Bradford, Oliver R. Steward, Silke Schelenz, James T. McColl, Bertrand Lézé, Norman van Rhijn, Alessandra da Silva Dantas, Takanori Furukawa, , Stefan M. Bidula
This study demonstrates that G-quadruplexes are a promising antifungal target, as ligands like PhenDC3 inhibit fungal pathogens and show synergistic effects with existing antifungals.
bioRxiv · Mar 1, 2025 · PreprintMicrobiology