James T. McColl

Epidermal Growth Factor/c-Met receptor signalling crosstalk drives tunneling nanotube formation in A549 lung adenocarcinoma cells

This study shows that EGFR and c-Met signaling crosstalk drives tunneling nanotube formation in A549 cells, with dual inhibition needed to block TNTs when both EGF and HGF are present.

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

The paper shows that T-cell activation is initiated by partial CD45 exclusion at sub-micron contacts, leading to strong activation and cytotoxicity through small signaling changes.

G-quadruplexes represent promising new targets to overcome multidrug-resistant fungal infections

This study demonstrates that G-quadruplexes are a promising antifungal target, as ligands like PhenDC3 inhibit fungal pathogens and show synergistic effects with existing antifungals.

4D imaging reveals stage dependent random and directed cell motion during somite morphogenesis

The paper uses live imaging to study cell movement during somite formation in chick embryos, revealing both random and directed motion in different regions.