Author

Silke Schelenz

King's College LondonORCID 0000-0002-0108-4619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:DNA methylation· 2 Organism:fungi (other)· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:genome assembly· 1

Frequent Co-Authors

Alireza AbdolrasouliiD· 4 shared Johanna L. RhodesiD· 3 shared Matthew C. FisheriD· 3 shared Amelie P. Brackin· 2 shared Andrew M. BormaniD· 2 shared Darius P. H. Armstrong-JamesiD· 2 shared Elizabeth M. JohnsoniD· 2 shared Norman van RhijniD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersGenomics

Alireza AbdolrasouliORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

G-quadruplexes represent promising new targets to overcome multidrug-resistant fungal infections

Georgie Middleton, Fuad O Mahamud, Isabelle S. R. Storer, Abigail Williams-Gunn, Finn Wostear, Alireza Abdolrasouli, Elaine Barclay, Alice Bradford, Oliver R. Steward, Silke Schelenz, James T. McColl, Bertrand Lézé, Norman van Rhijn, Alessandra da Silva Dantas, Takanori Furukawa, , Stefan M. Bidula

This study demonstrates that G-quadruplexes are a promising antifungal target, as ligands like PhenDC3 inhibit fungal pathogens and show synergistic effects with existing antifungals.

bioRxiv · Mar 1, 2025 · PreprintMicrobiology

Genomic epidemiology of emerging terbinafine-resistant Trichophyton indotineae

Johanna L. Rhodes, Sui Ting Hui, Sarah Dellière, Richard C. Summerbell, James A. Scott, Amtoj Kaur, Richard Barton, Rodrigo Leitao, Samuel Hemmings, Rebeca Goiriz, Jonathan Lambourne, Rhys A. Farrer, Silke Schelenz, Roderick J. Hay, Andrew M. Borman, , Matthew C. Fisher

The paper identifies terbinafine-resistant Trichophyton indotineae isolates globally, finds high genetic similarity and resistance linked to SQLE mutations, and suggests alternative resistance mechanisms.

bioRxiv · Oct 29, 2024 · PreprintGenomics

Genomic epidemiology of Candida auris introduction and outbreaks in the United Kingdom

Dana Kappel, Hugh Gifford, Amelie P. Brackin, Alireza Abdolrasouli, David W. Eyre, Katie JM Jeffery, Silke Schelenz, David M. Aanensen, Colin Stewart Brown, Andrew M. Borman, Elizabeth M. Johnson, Alison Helen Holmes, Darius P. H. Armstrong-James, Matthew C. Fisher, Johanna L. Rhodes

This study uses genomic data to trace the introduction and transmission of Candida auris in the UK between 2014 and 2019, identifying at least three introductions and multiple transmission events.

bioRxiv · Jan 15, 2024 · PreprintGenomics

Tracing patterns of evolution and acquisition of drug resistant Aspergillus fumigatus infection from the environment using population genomics

Johanna L. Rhodes, Alireza Abdolrasouli, Katie Dunne, Thomas R. Sewell, Yuyi Zhang, Eloise Ballard, Amelie P. Brackin, Norman van Rhijn, Alexandra Tsitsopoulou, Raquel B. Posso, Sanjay Haresh Chotirmall, Noel Gerard McElvaney, Philip G. Murphy, Alida Fe Talento, Julie Renwick, , Matthew C. Fisher

The paper uses population genomics to trace the evolution and environmental acquisition of drug-resistant Aspergillus fumigatus, finding evidence of resistant isolates transmitted from the environment to patients.

bioRxiv · Apr 7, 2021 · PreprintGenomics