Pluripotency factors regulate the onset of Hox cluster activation in the early embryo
Elena Lopez-Jimenez, Julio Sainz de Aja, Claudio Badía-Careaga, Antonio Barral, Isabel Rollán, Raquel Rouco, Elisa Santos, María Tiana, Jesús Victorino, Héctor Sánchez-Iranzo, Rafael D. Acemel, Carlos Torroja, Javier Adan, Eduardo Andrés‐León, José Luis Gómez-Skármeta, , Miguel Manzanares
This study shows pluripotency factors like OCT4 and NANOG initially repress and later enable activation of lineage specifiers, including the HoxB cluster, during early embryonic development.
Science Advances · Jul 15, 2022Peer-reviewedDevelopmental Biology