Establishment of 3D chromatin structure after fertilization and the metabolic switch at the morula-to-blastocyst transition require CTCF
María José Andreu, Alba Alvarez-Franco, Marta Portela…·Miguel Manzanares
This study shows that CTCF is essential for establishing 3D chromatin structure and regulating metabolic and protein homeostasis during early mouse development, but these functions operate independently.