Isabel Rollán

This study shows pluripotency factors like OCT4 and NANOG initially repress and later enable activation of lineage specifiers, including the HoxB cluster, during early embryonic development.

The paper identifies novel enhancers and silencers linked to atrial fibrillation using an in vivo mouse reporter assay system with increased throughput.

This study identifies Nanog as a repressor of Pou3f1, which inhibits anterior neural fate during gastrulation in mouse embryos.

The paper identifies a human accelerated region in Chromosome 14q12 that enhances forebrain expansion through increased enhancer activity in transgenic mice and organoids.

This study identifies Notch's role in driving cell potency transitions during early mouse development, revealing novel targets and interactions with Hippo signaling.