Crosstalk between thrombospondin-1 and CD36 modulates platelet-RBC interaction limiting thrombosis and abdominal aneurysm formation
Kim Jürgen Krott, Tobias Feige, Agnes Bosbach, Alicia Beele, Irena Krüger, Friedrich Reusswig, Elena Schickentanz-Dey, Susanne Pfeiler, Alexandra Chadt, Malte Kelm, Norbert Gerdes, Kerstin Jurk, Klytaimnistra Kiouptsi, Christoph Reinhardt, Hadi Al‐Hasani, , Margitta Elvers
This study identifies a novel CD36-TSP-1 signaling pathway that modulates platelet-RBC interaction, promoting thrombus formation and contributing to abdominal aortic aneurysm pathology.
Circulation Research · Oct 27, 2025Peer-reviewedPathology