Norbert Gerdes

An Apoptotic Failsafe Program Involving PDGF-dependent PI 3-Kinase Activity Contributes to Plaque Composition in Atherosclerosis

This study shows that chronic PDGF signaling increases VSMC apoptosis in atherosclerotic plaques by promoting PI3K-dependent c-Myc expression and reducing Bcl-2, leading to plaque instability.

Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction

This study shows that anemia in coronary artery disease patients increases release of red blood cell-derived extracellular vesicles (REVs) that promote endothelial dysfunction by enhancing nitric oxide consumption and oxidative stress.

Crosstalk between thrombospondin-1 and CD36 modulates platelet-RBC interaction limiting thrombosis and abdominal aneurysm formation

This study identifies a novel CD36-TSP-1 signaling pathway that modulates platelet-RBC interaction, promoting thrombus formation and contributing to abdominal aortic aneurysm pathology.

Olfactory receptor 2 drives abdominal aortic aneurysm by promoting CX3CR1-mediated monocyte recruitment

This study shows that Olfr2 promotes abdominal aortic aneurysm by enhancing CX3CR1-mediated monocyte recruitment through inflammatory pathways.

Novel fluorescence-based methods to determine infarct and scar size in murine models of reperfused myocardial infarction

The paper compares fluorescence staining methods to classical histochemical techniques for determining infarct and scar size in murine reperfused myocardial infarction models.

Distinct effects of acute and chronic blood loss anemia on vascular function after acute myocardial infarction

This study compares the effects of acute and chronic blood loss anemia on vascular function after myocardial infarction in mice, finding both types impair endothelial function with chronic anemia additionally reducing vascular smooth muscle contractility.

Colchicine inhibited oxidative stress-induced endothelial cell senescence via blocking NF-κB and MAPKs: Implications in vascular diseases

Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

The paper uses long-read mRNA sequencing to analyze PGC-1α transcripts in murine and human hearts, identifying novel isoforms and promoters regulated in ischemia and obesity.