Comprehensive and accelerated mapping of driver mutations through single-nucleotide random mutagenesis of target genes
Keisuke Yoshida, Elena Solovieva, Nami Miura, Shigeyuki Shichino, Michiaki Hamada, Masafumi Muratani, Takanori Amano, Kazufumi Honda
This study introduces a genome editing method to rapidly generate and test driver mutations in target genes, identifying novel resistance mutations in lung cancer.
bioRxiv · Nov 5, 2025 · PreprintBioengineering