Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer
Dario De Felice, Alessandro Alaimo, Davide Bressan, Sacha Genovesi, Elisa Marmocchi, Nicole Annesi, Giulia Beccaceci, Davide Dalfovo, Federico Cutrupi, Stefano Medaglia, Veronica Foletto, Marco Lorenzoni, Francesco Gandolfi, Srinivasaraghavan Kannan, Chandra Shekhar Verma, , Andrea Lunardi
This study shows RA signaling promotes luminal identity in prostate progenitors through Foxa1, and identifies a loss-of-function mutation in Foxa1 linked to prostate cancer dedifferentiation.
EMBO Reports · Dec 4, 2024Peer-reviewedCancer Biology