Alessandro Romanel

The paper identifies a tranSNP in DDIT4 mRNA that affects translation efficiency and modulates p53-dependent responses in cancer cells.

This study shows RA signaling promotes luminal identity in prostate progenitors through Foxa1, and identifies a loss-of-function mutation in Foxa1 linked to prostate cancer dedifferentiation.

This study investigates how common EXO5 haplotypes affect protein structure, dynamics, and cancer progression using genomic, clinical, and simulation data.

This study identifies YTHDF paralogs and VIRMA as major tumor drivers among m6A core genes through a pan-cancer analysis of 10,000 samples.

This study identifies molecular subgroups of BPH and suggests mTOR inhibitors as a potential therapy for specific subtypes.

EthSEQ annotates ethnicity from whole exome sequencing data with high precision, validated on 1,000 Genome Project and TCGA datasets.

This study reports that 17% of advanced cancer patients have clinically relevant germline variants, with higher rates of cancer-associated variants compared to control cohorts.