Higher-order inter-chromosomal hubs shape 3-dimensional genome organization in the nucleus
Sofia A. Quinodoz, Noah Ollikainen, Barbara Tabak, Ali Palla, Jan Marten Schmidt, Elizabeth Detmar, Mason Lai, Alexander A. Shishkin, Prashant Bhat, Yodai Takei, Vickie Trinh, Erik I. Aznauryan, Pamela H. Russell, Christine S. Cheng, Marko Jovanović, , Mitchell Guttman
The paper introduces SPRITE, a method for detecting higher-order DNA interactions, and shows that nuclear bodies act as inter-chromosomal hubs shaping 3D genome organization.
Cell · Jun 7, 2018Peer-reviewedGenomics