Prashant Bhat

The paper integrates 4D Nucleome data to analyze 3D genome structure and function in human cells, revealing chromatin domains, loops, and interactions, and showing how genetic variants affect genome folding.

The paper maps rRNA processing dynamics in the nucleolus and shows how rRNA processing affects nucleolar phase organization and structure.

This study uses high-resolution spatial multi-omics to analyze subnuclear compartments in single cells, revealing cell-type specific chromatin structures and their genomic associations.

The paper shows that gene proximity to nuclear speckles increases spliceosome binding and co-transcriptional splicing efficiency, highlighting the role of 3D genome organization in mRNA splicing.

The paper develops RD-SPRITE to map RNA-DNA and RNA-RNA interactions in 3D nuclear structures, revealing RNA's role in forming compartments that regulate nuclear functions.

The paper introduces SPRITE, a method for detecting higher-order DNA interactions, and shows that nuclear bodies act as inter-chromosomal hubs shaping 3D genome organization.