Christine S. Cheng

The paper develops a 3D neuron-astrocyte coculture model to study tauopathy, showing it recapitulates pathological features and responds to HSP90 inhibitor treatment.

The paper identifies a de novo FOXR1 variant causing microcephaly and brain atrophy by impairing stress response pathways.

This study uses scRNA-seq to show chronic opioid use suppresses antiviral gene programs in immune cells, both acutely and chronically, highlighting potential immune system harm.

The paper identifies genetic variants affecting chromatin accessibility in T cells and links them to gene expression and autoimmune disease.

The paper introduces SPRITE, a method for detecting higher-order DNA interactions, and shows that nuclear bodies act as inter-chromosomal hubs shaping 3D genome organization.