Mitochondrial Phosphopantetheinylation is Required for Oxidative Function
Pieter R. Norden, Riley J. Wedan, Samuel E.J. Preston, Morgan T. Canfield, Naomi Graber, Jacob Z. Longenecker, Olivia A. Pentecost, Elizabeth McLaughlin, Madeleine L. Hart, Sara M. Nowinski
This study identifies AASDHPPT as a mitochondrial PPTase essential for mtFAS and oxidative function, with human variants linked to pathogenic effects.
Metabolism · Oct 7, 2025Peer-reviewedMolecular Biology