Author

Jacob Z. Longenecker

Van Andel Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Morgan T. Canfield· 2 shared Pieter R. NordeniD· 2 shared Riley J. WedaniD· 2 shared Sara M. NowinskiiD· 2 shared Abigail E. EllisiD· 1 shared Elizabeth McLaughlin· 1 shared Madeleine L. HartiD· 1 shared Michelle L. Dykstra· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Morgan T. Canfield

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2 papers

Recent·Most cited

Cells Engage Endogenous Malonate Synthesis to Drive Mitochondrial Metabolism

Riley J. Wedan, Pieter R. Norden, Morgan T. Canfield, Abigail E. Ellis, Sanskriti Saxena, Jacob Z. Longenecker, Michelle L. Dykstra, Ryan D. Sheldon, Sara M. Nowinski

The paper identifies malonate as an endogenous intermediate supporting mitochondrial fatty acid synthesis and oxidative phosphorylation, showing ACC1-dependent synthesis from glucose.

bioRxiv · May 29, 2026 · PreprintBiochemistry

Mitochondrial Phosphopantetheinylation is Required for Oxidative Function

Pieter R. Norden, Riley J. Wedan, Samuel E.J. Preston, Morgan T. Canfield, Naomi Graber, Jacob Z. Longenecker, Olivia A. Pentecost, Elizabeth McLaughlin, Madeleine L. Hart, Sara M. Nowinski

This study identifies AASDHPPT as a mitochondrial PPTase essential for mtFAS and oxidative function, with human variants linked to pathogenic effects.

Metabolism · Oct 7, 2025Peer-reviewedMolecular Biology