Author

Morgan T. Canfield

Van Andel Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

Pieter R. NordeniD· 3 shared Riley J. WedaniD· 3 shared Sara M. NowinskiiD· 3 shared Abigail E. EllisiD· 2 shared Jacob Z. Longenecker· 2 shared Madeleine L. HartiD· 2 shared Ryan D. SheldoniD· 2 shared Elizabeth McLaughlin· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiochemistry

Pieter R. NordenORCID

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Author profile →

3 papers

Recent·Most cited

Functional partitioning of lipoic acid decouples cellular abundance from mitochondrial utilization

Pieter R. Norden, Riley J. Wedan, Abigail E. Ellis, Madeleine L. Hart, Megan R. Gendjar, Morgan T. Canfield, Ryan D. Sheldon, Sara M. Nowinski

This study shows that lipoic acid exists in two distinct cellular pools with different functions, and supplementation increases free LA without restoring mitochondrial function.

Journal of Lipid Research · Aug 20, 2026Peer-reviewedBiochemistry

Cells Engage Endogenous Malonate Synthesis to Drive Mitochondrial Metabolism

Riley J. Wedan, Pieter R. Norden, Morgan T. Canfield, Abigail E. Ellis, Sanskriti Saxena, Jacob Z. Longenecker, Michelle L. Dykstra, Ryan D. Sheldon, Sara M. Nowinski

The paper identifies malonate as an endogenous intermediate supporting mitochondrial fatty acid synthesis and oxidative phosphorylation, showing ACC1-dependent synthesis from glucose.

bioRxiv · May 29, 2026 · PreprintBiochemistry

Mitochondrial Phosphopantetheinylation is Required for Oxidative Function

Pieter R. Norden, Riley J. Wedan, Samuel E.J. Preston, Morgan T. Canfield, Naomi Graber, Jacob Z. Longenecker, Olivia A. Pentecost, Elizabeth McLaughlin, Madeleine L. Hart, Sara M. Nowinski

This study identifies AASDHPPT as a mitochondrial PPTase essential for mtFAS and oxidative function, with human variants linked to pathogenic effects.

Metabolism · Oct 7, 2025Peer-reviewedMolecular Biology