Pieter R. Norden

Functional partitioning of lipoic acid decouples cellular abundance from mitochondrial utilization

This study shows that lipoic acid exists in two distinct cellular pools with different functions, and supplementation increases free LA without restoring mitochondrial function.

Cells Engage Endogenous Malonate Synthesis to Drive Mitochondrial Metabolism

The paper identifies malonate as an endogenous intermediate supporting mitochondrial fatty acid synthesis and oxidative phosphorylation, showing ACC1-dependent synthesis from glucose.

Mitochondrial Phosphopantetheinylation is Required for Oxidative Function

This study identifies AASDHPPT as a mitochondrial PPTase essential for mtFAS and oxidative function, with human variants linked to pathogenic effects.

Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury

This study identifies FOXC1 and FOXC2 as essential regulators of intestinal regeneration after ischemia-reperfusion injury by promoting paracrine signaling from endothelial cells.

Differential roles of neural crest- and endothelial-derived FOXC2 in trabecular meshwork and Schlemms Canal in glaucomatous pathology

The paper investigates the role of FOXC2 in neural crest- and endothelial-derived cells in the trabecular meshwork and Schlemms Canal, showing its importance in development and maintenance of the aqueous humor outflow pathway in glaucoma.