A druggable ATP13A3-antizyme switch controls adaptive polyamine uptake in cancer
Alain René Schoofs, Jialin Chen, Rania Abou El Asrar, Eline Ryckaert, Lennert Delarbre, Mujahid Azfar, Natalie Gia-Hue Lũ, Arti Sukhai, Marijke De Jaeger, Stephanie Vrijsen, Suravi Chakrabarty, Jolien Bejster, Emily Meeus, Youri Fayt, Anna Vercauteren, , Peter Vangheluwe
This study identifies ATP13A3-antizyme regulation as a mechanism for adaptive polyamine uptake in cancer, showing that targeting ATP13A3 with AMXT 1501 can block this response.
bioRxiv · Jul 1, 2026 · PreprintCell Biology