Peter Vangheluwe

A druggable ATP13A3-antizyme switch controls adaptive polyamine uptake in cancer

This study identifies ATP13A3-antizyme regulation as a mechanism for adaptive polyamine uptake in cancer, showing that targeting ATP13A3 with AMXT 1501 can block this response.

ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte Toxicity

The paper shows ATP13A2 loss of function disrupts polyamine metabolism, leading to SAM depletion and epigenetic astrocyte toxicity, which contributes to Parkinson's disease.

Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits

This study shows that ATP10B loss causes dopaminergic neuron death and Parkinsonian symptoms in rats and human stem cell models.

Genetically encoded fluorescent sensors for visualizing polyamine levels, uptake, and distribution

This paper develops genetically encoded fluorescent sensors to measure polyamine levels, uptake, and distribution in cells, revealing compounds that modulate polyamine levels.

Functional characterization of ATP13A2 variants associated with distinct neurodegenerative disorders

The paper functionally characterizes ATP13A2 variants linked to neurodegenerative disorders, finding that only the homozygous NCL variant causes complete loss-of-function, while others show subtle defects.